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Liver Cancer Clinical Trials

Category:Adult
Status:Active

Displaying all 13 Trial

A Study of Ramucirumab (LY3009806) Versus Placebo in Participants With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein

The purpose of this study is to evaluate the safety and efficacy of ramucirumab in participants with hepatocellular carcinoma (HCC) and elevated baseline alpha-fetoprotein. Participants will be ran...

Diagnosis: Gastrointestinal Malignancies, Liver Cancer

Phase: 3

Protocol Number: 15-287

Sorafenib + mFOLFOX for Hepatocellular Carcinoma

This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational combination of drugs to learn whether the drug combination works in treating ...

Diagnosis: Gastrointestinal Malignancies, Liver Cancer

Phase: 2

Protocol Number: 12-218

Safety and Efficacy of FGF401 in Patients With Solid Malignancies

Estimate the maximum tolerated dose and/or recommended phase two dose and efficacy of FGF401 on patients with solid malignancies

Diagnosis: Gastrointestinal Malignancies, Stomach Cancer, Liver Cancer, Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer

Phase: 1 / 2

Protocol Number: 14-464

rRp450-Phase I Trial in Liver Metastases and Primary Liver Tumors

The purpose of this research study is to determine the safety of rRp450 and the highest dose of this agent that can be given to people safely. We are also looking to see how well the body tolerates...

Diagnosis: Liver Cancer

Phase: 1

Protocol Number: 09-042

Effect of Surefire Infusion Device on Tumor Response to Regional Intra-arterial Therapy for Primary Liver Malignancies

This research study is studying the Surefire Infusion System ("Surefire") for increasing delivery of chemotherapeutic agents delivered trans-arterially to intermediate stage Hepatocellula...

Diagnosis: Liver Cancer, Gastrointestinal Malignancies

Phase: N/A

Protocol Number: 16-077

A Phase 1 Study of BLU-554 in Patients With Hepatocellular Carcinoma

This is a Phase 1, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of BLU...

Diagnosis: Liver Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 16-076

Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer

This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer. The interventions involved in this study are: - T...

Diagnosis: Colorectal Cancer, Liver Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 17-231

AFPᶜ³³²T in Advanced HCC

This study will investigate the safety and tolerability of AFPᶜ³³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker, whose liver tumor has the AFP protein and whose nonc...

Diagnosis: Liver Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 17-033

A Trial of Lenvatinib Plus Pembrolizumab in Subjects With Hepatocellular Carcinoma

This is an open-label Phase 1b study designed to evaluate the tolerability and safety of lenvatinib in combination with pembrolizumab in participants with hepatocellular carcinoma (HCC).

Diagnosis: Liver Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 17-524

Radiation Therapy With Protons or Photons in Treating Patients With Liver Cancer

This phase III trial studies how well radiation therapy with protons works compared with photons in treating patients with liver cancer. Radiation therapy, such as photon therapy, uses high energy ...

Diagnosis: Gastrointestinal Malignancies, Liver Cancer

Phase:

Protocol Number: 17-733

Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

This research study is studying a combination of drugs as a possible treatment for Hepatocellular Carcinoma or Biliary Tract Cancer. The interventions involved in this study are: - Durvalumab - Tre...

Diagnosis: Liver Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 17-517

Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

This partially randomized phase II/III trial studies how well cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or liver cancer after surgery. D...

Diagnosis: Liver Cancer

Phase:

Protocol Number: 18-721

Safety, Preliminary Efficacy and PK of Isatuximab (SAR650984) Alone or in Combination With Atezolizumab in Patients With Advanced Malignancies

Primary Objectives: - Phase1: To characterize the safety and tolerability of isatuximab in combination with atezolizumab in participants with unresectable hepatocellular carcinoma (HCC), platinum-r...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma, Head and Neck Cancer, GYN: Ovarian, Fallopian, Peritoneal Cancer, Liver Cancer

Phase:

Protocol Number: 18-332

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