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Pediatric Brain Tumor Clinical Trials

Category:Pediatric
Status:Active

Displaying all 17 trials

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma

This randomized phase III trial studies different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, hi...

Diagnosis: Pediatric Brain Tumor, Pediatric Oncology

Phase: 3

Protocol Number: 07-125

Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma

This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patien...

Diagnosis: Pediatric Oncology, Pediatric Brain Tumor

Phase: 3

Protocol Number: 10-239

Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas

To determine the hearing response rate at 24 weeks after treatment with bevacizumab for symptomatic vestibular schwannomas (VS) in children and young adults with NF2.

Diagnosis: Pediatric Brain Tumor

Phase: 2

Protocol Number: 12-466

A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer

The main purpose of this study is to evaluate the safety of different doses of olaratumab and to determine which dose should be used for future pediatric studies. The present study is open to child...

Diagnosis: Pediatric Brain Tumor, Pediatric Solid Tumors, Pediatric Sarcoma, Pediatric Neuroblastoma

Phase: 1

Protocol Number: 16-196

Neuropsychological and Behavioral Testing in Younger Patients With Cancer

This research trial studies neuropsychological (learning, remembering or thinking) and behavioral testing in younger patients with cancer. Collecting information over time from a series of tests ma...

Diagnosis: Pediatric Brain Tumor

Phase: N/A

Protocol Number: 08-363

Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissu...

Diagnosis: Pediatric Brain Tumor

Phase: N/A

Protocol Number: 04-333

Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma

Participants enrolling on this study will receive standard of care chemotherapy for Wnt positive medulloblastoma without the radiation therapy or the weekly chemotherapy that is given during radiat...

Diagnosis: Pediatric Brain Tumor

Phase: N/A

Protocol Number:

A Study to Determine Safety, Tolerability and Pharmacokinetics of Oral Dabrafenib In Children and Adolescent Subjects

This is a 2-part, study to determine the safety, tolerability and pharmacokinetics of oral dabrafenib in children and adolescent subjects with advanced BRAF V600 mutation-positive solid tumors. Par...

Diagnosis: Pediatric Solid Tumors, Pediatric Brain Tumor

Phase:

Protocol Number: 12-429

PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children

This is an open label study of everolimus in children with recurrent or progressive low-grade glioma.

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 15-369

WEE1 Inhibitor MK-1775 and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors

This phase I/II trial studies the side effects and best dose of WEE1 inhibitor MK-1775 and irinotecan hydrochloride in treating younger patients with solid tumors that have come back or that have n...

Diagnosis: Pediatric Solid Tumors, Pediatric Brain Tumor

Phase:

Protocol Number: 16-447

Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas

This study is to evaluate the efficacy and safety of ABT-414 alone or with temozolomide versus temozolomide or lomustine alone in participants with recurrent glioblastoma multiforme. The study incl...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 16-543

Molecular Profiling for Individualized Treatment Plan for DIPG

This is a single arm multi-center pilot trial within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). The current study will use a new treatment approach based on each patient's tumor ge...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 16-292

Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treatments for...

Diagnosis: Pediatric Oncology, Pediatric Brain Tumor

Phase:

Protocol Number: 17-726

H3.3K27M Peptide Vaccine for Children With Newly Diagnosed DIPG and Other Gliomas

This is a two cohort Phase I study within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). This study will assess the safety of repeated administration of the H3.3K27M specific vaccine in HL...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 16-619

An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies

The purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (CN...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-221

A Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

A Phase 2 study that will assess the efficacy, safety and tolerability of pomalidomide in children and young adults aged 1 to < 21 years with recurrent or progressive primary brain tumors. The s...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-227

Study of Lorlatinib (PF-06463922)

Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in...

Diagnosis: Pediatric Brain Tumor, Pediatric Neuroblastoma

Phase:

Protocol Number: 17-393

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