Pediatric Brain Tumor Clinical Trials
Category:Pediatric
Status:Active
Displaying all 26 Trial
This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patien...
Diagnosis: Pediatric Oncology, Pediatric Brain Tumor
Phase: 3
Protocol Number: 10-239
Patients with relapsed medulloblastoma have a very poor prognosis whether treated with conventional chemotherapy, high-dose chemotherapy with stem cell rescue, irradiation or combinations of these ...
Diagnosis: Pediatric Brain Tumor
Phase: 2
Protocol Number: 13-359
Phase I/II Study of MEK162 for Children With Ras/Raf Pathway Activated Tumors
The main purpose of phase I studies in general is to determine the best dose ("maximum tolerated dose") of a drug, and to find out the most common side effects. The main purpose of the ph...
Diagnosis: Pediatric Brain Tumor
Phase: 1 / 2
Protocol Number: 15-368
Neuropsychological and Behavioral Testing in Younger Patients With Cancer
This research trial studies neuropsychological (learning, remembering or thinking) and behavioral testing in younger patients with cancer. Collecting information over time from a series of tests ma...
Diagnosis: Pediatric Brain Tumor
Phase: N/A
Protocol Number: 08-363
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors
The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissu...
Diagnosis: Pediatric Brain Tumor
Phase: N/A
Protocol Number: 04-333
Participants enrolling on this study will receive standard of care chemotherapy for Wnt positive medulloblastoma without the radiation therapy or the weekly chemotherapy that is given during radiat...
Diagnosis: Pediatric Brain Tumor
Phase: N/A
Protocol Number:
PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children
This is an open label study of everolimus in children with recurrent or progressive low-grade glioma.
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 15-369
This phase I/II trial studies the side effects and best dose of WEE1 inhibitor MK-1775 and irinotecan hydrochloride in treating younger patients with solid tumors that have come back or that have n...
Diagnosis: Pediatric Solid Tumors, Pediatric Brain Tumor
Phase:
Protocol Number: 16-447
This study is to evaluate the efficacy and safety of ABT-414 alone or with temozolomide versus temozolomide or lomustine alone in participants with recurrent glioblastoma multiforme. The study incl...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 16-543
Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma
This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treatments for...
Diagnosis: Pediatric Oncology, Pediatric Brain Tumor
Phase:
Protocol Number: 17-726
H3.3K27M Peptide Vaccine for Children With Newly Diagnosed DIPG and Other Gliomas
This is a two cohort Phase I study within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). This study will assess the safety of repeated administration of the H3.3K27M specific vaccine in HL...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 16-619
The purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (CN...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 17-221
A Phase 2 study that will assess the efficacy, safety and tolerability of pomalidomide in children and young adults aged 1 to < 21 years with recurrent or progressive primary brain tumors. The s...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 17-227
Study of Lorlatinib (PF-06463922)
Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in...
Diagnosis: Pediatric Brain Tumor, Pediatric Neuroblastoma
Phase:
Protocol Number: 17-393
This is a two arm Phase I study within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). This study will look to determine the safety and recommended phase 2 dose of the modified measles viru...
Diagnosis: Pediatric Neuroblastoma, Pediatric Brain Tumor
Phase:
Protocol Number: 17-103
A Two-Part Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma
The purpose of this study is to assess the safety and tolerability profile of TB-403 (humanized monoclonal antibody against placental growth factor (PlGF)) in pediatric subjects with relapsed or re...
Diagnosis: Pediatric Neuroblastoma, Pediatric Brain Tumor
Phase:
Protocol Number: 16-509
TAK-580 In Gliomas and Other Tumors
This research study is studying a drug TAK-580 (MLN2480) as a possible treatment a low-grade glioma that has not responded to other treatments. The name of the study drug involved in this study is:...
Diagnosis: Pediatric Oncology, Pediatric Brain Tumor
Phase:
Protocol Number: 17-589
A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors or DIPG
This research study involves an investigational product: Ad-RTS-hIL-12 given with veledimex for production of human IL-12. IL-12 is a protein that can improve the body's natural response to di...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 17-337
Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG
The purpose of this study is to investigate the activity of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive relapsed or refractory hig...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 17-532
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors
This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free surviva...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 17-708
Pilot Feasibility of the Pediatric Cancer Resource Equity (PediCARE) Intervention
The goal of this new intervention is to make it easier for families to meet their basic household needs during childhood cancer treatment. The investigators want to learn how to best use PediCARE t...
Diagnosis: Pediatric Brain Tumor, Pediatric Solid Tumors, Pediatric Hematology/Blood Related
Phase:
Protocol Number: 18-294
This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor cal...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 17-752
Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer
This research study is studying a novel drug called ALRN-6924 as a possible treatment for resistant (refractory) solid tumor, brain tumor, lymphoma or leukemia. The drugs involved in this study are...
Diagnosis: Pediatric Leukemia, Pediatric Brain Tumor, Pediatric Lymphoma, Pediatric Solid Tumors
Phase:
Protocol Number: 18-284
Developing Fast Pediatric Imaging
This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 18-325
Phase 1: To confirm the safety and anticipated recommended phase 2 dose (RP2D) of the PD-1 inhibitor REGN2810 (cemiplimab) for children with recurrent or refractory solid or CNS tumors and to chara...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 18-236
Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas
This is a phase II open label study that will evaluate children ≥ 1 year of age and adults with neurofibromatosis type 1 (NF1) and plexiform neurofibromas treated with the MEK inhibitor, binimetini...
Diagnosis: Pediatric Brain Tumor
Phase:
Protocol Number: 18-729
