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Pediatric Brain Tumor Clinical Trials

Category:Pediatric
Status:Active

Displaying all 25 Trial

Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma

This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patien...

Diagnosis: Pediatric Oncology, Pediatric Brain Tumor

Phase: 3

Protocol Number: 10-239

Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas

To determine the hearing response rate at 24 weeks after treatment with bevacizumab for symptomatic vestibular schwannomas (VS) in children and young adults with NF2.

Diagnosis: Pediatric Brain Tumor

Phase: 2

Protocol Number: 12-466

Metronomic and Targeted Anti-angiogenesis Therapy for Children With Recurrent/Progressive Medulloblastoma

Patients with relapsed medulloblastoma have a very poor prognosis whether treated with conventional chemotherapy, high-dose chemotherapy with stem cell rescue, irradiation or combinations of these ...

Diagnosis: Pediatric Brain Tumor

Phase: 2

Protocol Number: 13-359

Phase I/II Study of MEK162 for Children With Ras/Raf Pathway Activated Tumors

The main purpose of phase I studies in general is to determine the best dose ("maximum tolerated dose") of a drug, and to find out the most common side effects. The main purpose of the ph...

Diagnosis: Pediatric Brain Tumor

Phase: 1 / 2

Protocol Number: 15-368

A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer

The main purpose of this study is to evaluate the safety of different doses of olaratumab and to determine which dose should be used for future pediatric studies. The present study is open to child...

Diagnosis: Pediatric Brain Tumor, Pediatric Solid Tumors, Pediatric Sarcoma, Pediatric Neuroblastoma

Phase: 1

Protocol Number: 16-196

Neuropsychological and Behavioral Testing in Younger Patients With Cancer

This research trial studies neuropsychological (learning, remembering or thinking) and behavioral testing in younger patients with cancer. Collecting information over time from a series of tests ma...

Diagnosis: Pediatric Brain Tumor

Phase: N/A

Protocol Number: 08-363

Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissu...

Diagnosis: Pediatric Brain Tumor

Phase: N/A

Protocol Number: 04-333

Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma

Participants enrolling on this study will receive standard of care chemotherapy for Wnt positive medulloblastoma without the radiation therapy or the weekly chemotherapy that is given during radiat...

Diagnosis: Pediatric Brain Tumor

Phase: N/A

Protocol Number:

A Study to Determine Safety, Tolerability and Pharmacokinetics of Oral Dabrafenib In Children and Adolescent Subjects

This is a 2-part, study to determine the safety, tolerability and pharmacokinetics of oral dabrafenib in children and adolescent subjects with advanced BRAF V600 mutation-positive solid tumors. Par...

Diagnosis: Pediatric Solid Tumors, Pediatric Brain Tumor

Phase:

Protocol Number: 12-429

PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children

This is an open label study of everolimus in children with recurrent or progressive low-grade glioma.

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 15-369

WEE1 Inhibitor MK-1775 and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors

This phase I/II trial studies the side effects and best dose of WEE1 inhibitor MK-1775 and irinotecan hydrochloride in treating younger patients with solid tumors that have come back or that have n...

Diagnosis: Pediatric Solid Tumors, Pediatric Brain Tumor

Phase:

Protocol Number: 16-447

Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas

This study is to evaluate the efficacy and safety of ABT-414 alone or with temozolomide versus temozolomide or lomustine alone in participants with recurrent glioblastoma multiforme. The study incl...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 16-543

Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treatments for...

Diagnosis: Pediatric Oncology, Pediatric Brain Tumor

Phase:

Protocol Number: 17-726

H3.3K27M Peptide Vaccine for Children With Newly Diagnosed DIPG and Other Gliomas

This is a two cohort Phase I study within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). This study will assess the safety of repeated administration of the H3.3K27M specific vaccine in HL...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 16-619

An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies

The purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (CN...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-221

A Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

A Phase 2 study that will assess the efficacy, safety and tolerability of pomalidomide in children and young adults aged 1 to < 21 years with recurrent or progressive primary brain tumors. The s...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-227

Study of Lorlatinib (PF-06463922)

Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in...

Diagnosis: Pediatric Brain Tumor, Pediatric Neuroblastoma

Phase:

Protocol Number: 17-393

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT

This is a two arm Phase I study within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). This study will look to determine the safety and recommended phase 2 dose of the modified measles viru...

Diagnosis: Pediatric Neuroblastoma, Pediatric Brain Tumor

Phase:

Protocol Number: 17-103

A Two-Part Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma

The purpose of this study is to assess the safety and tolerability profile of TB-403 (humanized monoclonal antibody against placental growth factor (PlGF)) in pediatric subjects with relapsed or re...

Diagnosis: Pediatric Neuroblastoma, Pediatric Brain Tumor

Phase:

Protocol Number: 16-509

TAK-580 In Gliomas and Other Tumors

This research study is studying a drug TAK-580 (MLN2480) as a possible treatment a low-grade glioma that has not responded to other treatments. The name of the study drug involved in this study is:...

Diagnosis: Pediatric Oncology, Pediatric Brain Tumor

Phase:

Protocol Number: 17-589

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors or DIPG

This research study involves an investigational product: Ad-RTS-hIL-12 given with veledimex for production of human IL-12. IL-12 is a protein that can improve the body's natural response to di...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-337

Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG

The purpose of this study is to investigate the activity of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive relapsed or refractory hig...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-532

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free surviva...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-708

Pilot Feasibility of the Pediatric Cancer Resource Equity (PediCARE) Intervention

The goal of this new intervention is to make it easier for families to meet their basic household needs during childhood cancer treatment. The investigators want to learn how to best use PediCARE t...

Diagnosis: Pediatric Brain Tumor, Pediatric Solid Tumors, Pediatric Hematology/Blood Related

Phase:

Protocol Number: 18-294

Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor cal...

Diagnosis: Pediatric Brain Tumor

Phase:

Protocol Number: 17-752

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