Sarcoma Clinical Trials
Category:Adult
Status:Active
Displaying all 26 trials
Selinexor in Advanced Liposarcoma
This is a randomized, multicenter, double-blind, placebo-controlled, Phase 2-3 study of patients diagnosed with advanced unresectable dedifferentiated liposarcoma. Approximately 245 total patients ...
Diagnosis: Sarcoma
Phase: 2 / 3
Protocol Number: 16-171
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas
To study the feasibility of reducing the dose of preoperative radiotherapy in MLS (Myxoid Liposarcomas) from 50 Gy to 36 Gy while maintaining comparable clinicopathological responses.
Diagnosis: Sarcoma
Phase: 2
Protocol Number:
A Phase 2 Study of ABI-009 in Patients With Advanced Malignant PEComa
A phase 2 multi-center investigation of efficacy of ABI-009 (nab-rapamycin) in patients with advanced malignant perivascular epithelioid cell tumor (PEComa)
Diagnosis: Sarcoma
Phase: 2
Protocol Number:
This randomized phase II trial studies how well nivolumab with or without ipilimumab works in treating patients with sarcoma that has spread from the primary site to other parts of the body or cann...
Diagnosis: Sarcoma
Phase: 2
Protocol Number: 18-701
Proton or Photon RT for Retroperitoneal Sarcomas
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investiga...
Diagnosis: Sarcoma
Phase: 1 / 2
Protocol Number: 12-100
PLX9486 as a Single Agent and in Combination With PLX3397 in Patients With Advanced Solid Tumors
The goal of this clinical research study is to learn how PLX9486 may affect cancer cells with certain mutations in the KIT gene, specifically in patients with types of advanced solid tumors includi...
Diagnosis: Sarcoma
Phase: 1 / 2
Protocol Number: 15-122
A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma
The main purpose of this study is to evaluate the safety and efficacy of two anti-cancer drugs (gemcitabine and docetaxel) with and without the study drug known as olaratumab in participants with a...
Diagnosis: Sarcoma
Phase: 1 / 2
Protocol Number: 16-154
Phase I Study of Olaprib and Temozolomide for Ewings Sarcoma
This research study is a Phase I clinical trial, which tests the safety of an investigational drug or combination of drugs and also tries to define the appropriate dose of the combination of invest...
Diagnosis: Sarcoma
Phase: 1
Protocol Number: 13-115
A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies
This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antitumor activ...
Diagnosis: Sarcoma
Phase: 1
Protocol Number: 15-495
Effect of High Doses of Radiation on Bone Structure and Metabolism
This study is designed to characterize the effects of high energy radiation on bone breakdown, with a specific interest in reducing the rate of sacral fractures. Although radiation is very importan...
Diagnosis: Sarcoma
Phase: N/A
Protocol Number: 14-208
This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound ...
Diagnosis: Sarcoma
Phase: N/A
Protocol Number: 15-485
This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antineoplastic ...
Diagnosis: Sarcoma
Phase:
Protocol Number: 15-365
The purpose of this early (pilot) clinical trial is to test the effects (both good and bad) of chemotherapy and adoptive immunotherapy with T cells engineered to recognize NY-ESO-1 peptide in patie...
Diagnosis: Sarcoma
Phase:
Protocol Number: 15-591
The purpose of this study is to evaluate the safety of olaratumab plus pembrolizumab in participants with previously treated advanced or metastatic soft tissue sarcoma.
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-153
This is a study of TRC105 in combination with standard dose pazopanib compared to single agent pazopanib in patients with angiosarcoma not amenable to curative intent surgery (e.g., metastatic or b...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-135
MGCD516 in Advanced Liposarcoma and Other Soft Tissue Sarcomas
Primary Objective: - To assess the efficacy of MGCD516 in patients with advanced liposarcoma by evaluating the progression free rate at 12 weeks as compared historical controls. Secondary Objective...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-090
This is an open-label, multi-institutional phase II randomized study comparing neoadjuvant radiotherapy followed by surgical resection to neoadjuvant pembrolizumab with concurrent radiotherapy, fol...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-365
This phase II trial studies how well atezolizumab works in treating patients with alveolar soft part sarcoma that has not been treated, has spread from where it started to other places in the body ...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-727
This is a two center, 2 arm, Phase II study evaluating the combination of Ribociclib and Everolimus in patients with advanced DDL and LMS who have had at least 1 prior systemic therapy. Patients wi...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-233
This phase II trial studies how well trametinib works in treating patients with epithelioid hemangioendothelioma that has spread to other places in the body, nearby tissue or lymph nodes, or cannot...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-736
Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE)
This research study is studying a drug as a possible treatment for Angiosarcoma or Epithelioid hemangioendothelioma (EHE). -The drug involved in this study is Eribulin
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-355
This study evaluates the combination of CBT-1® and doxorubicin for the treatment of metastatic, unresectable sarcoma in patients who have progressed after treatment with 150mg/m2 or less of doxorub...
Diagnosis: Sarcoma
Phase:
Protocol Number: 16-626
This partially randomized phase I/II trial studies the side effects and best dose of sapanisertib and to see how well it works compared to pazopanib hydrochloride in treating patients with sarcoma ...
Diagnosis: Sarcoma
Phase:
Protocol Number: 18-707
Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)
This study has two parts. Part 1 will evaluate how pexidartinib affects the way the body processes CYP3A4 and CYP2C9 substrates using midazolam and tolbutamide, respectively, as probe agents. Part ...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-451
This is a 2‑arm, randomized, placebo-controlled, double‑blind, international, multicenter study comparing the efficacy of DCC-2618 to placebo in patients who have received treatment with prior anti...
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-671
This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patie...
Diagnosis: Sarcoma
Phase:
Protocol Number: 18-713
