Sarcoma Clinical Trials
Category:Adult
Status:Active
Displaying all 17 trials
Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be ...
Diagnosis: Sarcoma
Phase: 3
Protocol Number: 12-301
Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)
The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery. In order to avoid amputation fo...
Diagnosis: Sarcoma
Phase: 3
Protocol Number: 13-222
Selinexor in Advanced Liposarcoma
This is a randomized, multicenter, double-blind, placebo-controlled, Phase 2-3 study of patients diagnosed with advanced unresectable dedifferentiated liposarcoma. Approximately 245 total patients ...
Diagnosis: Sarcoma
Phase: 2 / 3
Protocol Number: 16-171
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas
To study the feasibility of reducing the dose of preoperative radiotherapy in MLS (Myxoid Liposarcomas) from 50 Gy to 36 Gy while maintaining comparable clinicopathological responses.
Diagnosis: Sarcoma
Phase: 2
Protocol Number:
A Phase 2 Study of ABI-009 in Patients With Advanced Malignant PEComa
A phase 2 multi-center investigation of efficacy of ABI-009 (nab-rapamycin) in patients with advanced malignant perivascular epithelioid cell tumor (PEComa)
Diagnosis: Sarcoma
Phase: 2
Protocol Number:
This is a Phase II, multicenter, open-label, single arm, 2-stage study of tazemetostat 800 mg BID administered orally in continuous 28 day cycles. Screening of subjects to determine eligibility for...
Diagnosis: Sarcoma
Phase: 2
Protocol Number: 15-512
Proton or Photon RT for Retroperitoneal Sarcomas
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investiga...
Diagnosis: Sarcoma
Phase: 1 / 2
Protocol Number: 12-100
PLX9486 as a Single Agent and in Combination With PLX3397 in Patients With Advanced Solid Tumors
The goal of this clinical research study is to learn how PLX9486 may affect cancer cells with certain mutations in the KIT gene, specifically in patients with types of advanced solid tumors includi...
Diagnosis: Sarcoma
Phase: 1 / 2
Protocol Number: 15-122
Phase I Study of Olaprib and Temozolomide for Ewings Sarcoma
This research study is a Phase I clinical trial, which tests the safety of an investigational drug or combination of drugs and also tries to define the appropriate dose of the combination of invest...
Diagnosis: Sarcoma
Phase: 1
Protocol Number: 13-115
A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies
This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antitumor activ...
Diagnosis: Sarcoma
Phase: 1
Protocol Number: 15-495
Effect of High Doses of Radiation on Bone Structure and Metabolism
This study is designed to characterize the effects of high energy radiation on bone breakdown, with a specific interest in reducing the rate of sacral fractures. Although radiation is very importan...
Diagnosis: Sarcoma
Phase: N/A
Protocol Number: 14-208
This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound ...
Diagnosis: Sarcoma
Phase: N/A
Protocol Number: 15-485
This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antineoplastic ...
Diagnosis: Sarcoma
Phase:
Protocol Number: 15-365
ABBV-085, an Antibody Drug Conjugate, in Subjects With Advanced Solid Cancer Tumors
This is an open-label dose escalation study designed to evaluate the safety and pharmacokinetics of ABBV-085 and determine the recommended Phase 2 dose (as monotherapy or in combination with standa...
Diagnosis: Sarcoma
Phase:
Protocol Number: 15-428
PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors
The purpose of this study is to determine if treatment with PLX3397 and Sirolimus will be tolerated and result in shrinking of the cancer or stopping the cancer from growing. In the phase I portion...
Diagnosis: Sarcoma
Phase:
Protocol Number: 16-048
The purpose of this early (pilot) clinical trial is to test the effects (both good and bad) of chemotherapy and adoptive immunotherapy with T cells engineered to recognize NY-ESO-1 peptide in patie...
Diagnosis: Sarcoma
Phase:
Protocol Number: 15-591
The purpose of this study is to evaluate the safety of olaratumab plus pembrolizumab in participants with previously treated advanced or metastatic soft tissue sarcoma.
Diagnosis: Sarcoma
Phase:
Protocol Number: 17-153
