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Sarcoma Clinical Trials

Category:Adult
Status:Active

Displaying all 17 trials

Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be ...

Diagnosis: Sarcoma

Phase: 3

Protocol Number: 12-301

Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)

The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery. In order to avoid amputation fo...

Diagnosis: Sarcoma

Phase: 3

Protocol Number: 13-222

Selinexor in Advanced Liposarcoma

This is a randomized, multicenter, double-blind, placebo-controlled, Phase 2-3 study of patients diagnosed with advanced unresectable dedifferentiated liposarcoma. Approximately 245 total patients ...

Diagnosis: Sarcoma

Phase: 2 / 3

Protocol Number: 16-171

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas

To study the feasibility of reducing the dose of preoperative radiotherapy in MLS (Myxoid Liposarcomas) from 50 Gy to 36 Gy while maintaining comparable clinicopathological responses.

Diagnosis: Sarcoma

Phase: 2

Protocol Number:

A Phase 2 Study of ABI-009 in Patients With Advanced Malignant PEComa

A phase 2 multi-center investigation of efficacy of ABI-009 (nab-rapamycin) in patients with advanced malignant perivascular epithelioid cell tumor (PEComa)

Diagnosis: Sarcoma

Phase: 2

Protocol Number:

A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma

This is a Phase II, multicenter, open-label, single arm, 2-stage study of tazemetostat 800 mg BID administered orally in continuous 28 day cycles. Screening of subjects to determine eligibility for...

Diagnosis: Sarcoma

Phase: 2

Protocol Number: 15-512

Proton or Photon RT for Retroperitoneal Sarcomas

This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investiga...

Diagnosis: Sarcoma

Phase: 1 / 2

Protocol Number: 12-100

PLX9486 as a Single Agent and in Combination With PLX3397 in Patients With Advanced Solid Tumors

The goal of this clinical research study is to learn how PLX9486 may affect cancer cells with certain mutations in the KIT gene, specifically in patients with types of advanced solid tumors includi...

Diagnosis: Sarcoma

Phase: 1 / 2

Protocol Number: 15-122

Phase I Study of Olaprib and Temozolomide for Ewings Sarcoma

This research study is a Phase I clinical trial, which tests the safety of an investigational drug or combination of drugs and also tries to define the appropriate dose of the combination of invest...

Diagnosis: Sarcoma

Phase: 1

Protocol Number: 13-115

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antitumor activ...

Diagnosis: Sarcoma

Phase: 1

Protocol Number: 15-495

Effect of High Doses of Radiation on Bone Structure and Metabolism

This study is designed to characterize the effects of high energy radiation on bone breakdown, with a specific interest in reducing the rate of sacral fractures. Although radiation is very importan...

Diagnosis: Sarcoma

Phase: N/A

Protocol Number: 14-208

Effects Of Caloric Restriction On Post-Operative Complications In Sarcoma Patients Treated With Pre-Operative Radiation Therapy

This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound ...

Diagnosis: Sarcoma

Phase: N/A

Protocol Number: 15-485

Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors

This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antineoplastic ...

Diagnosis: Sarcoma

Phase:

Protocol Number: 15-365

ABBV-085, an Antibody Drug Conjugate, in Subjects With Advanced Solid Cancer Tumors

This is an open-label dose escalation study designed to evaluate the safety and pharmacokinetics of ABBV-085 and determine the recommended Phase 2 dose (as monotherapy or in combination with standa...

Diagnosis: Sarcoma

Phase:

Protocol Number: 15-428

PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

The purpose of this study is to determine if treatment with PLX3397 and Sirolimus will be tolerated and result in shrinking of the cancer or stopping the cancer from growing. In the phase I portion...

Diagnosis: Sarcoma

Phase:

Protocol Number: 16-048

A Pilot Study of Genetically Engineered NY-ESO-1 Specific NY-ESO-1ᶜ²⁵⁹T in HLA-A2+ Patients With Synovial Sarcoma

The purpose of this early (pilot) clinical trial is to test the effects (both good and bad) of chemotherapy and adoptive immunotherapy with T cells engineered to recognize NY-ESO-1 peptide in patie...

Diagnosis: Sarcoma

Phase:

Protocol Number: 15-591

A Study of Olaratumab (LY3012207) Plus Pembrolizumab in Participants With Advanced or Metastatic Soft Tissue Sarcoma

The purpose of this study is to evaluate the safety of olaratumab plus pembrolizumab in participants with previously treated advanced or metastatic soft tissue sarcoma.

Diagnosis: Sarcoma

Phase:

Protocol Number: 17-153

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