Pediatric Sarcoma Clinical Trials


Displaying all 10 trials

Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

This randomized phase III trial studies how well combination chemotherapy (vincristine sulfate, dactinomycin, cyclophosphamide alternated with vincristine sulfate and irinotecan hydrochloride) work...

Diagnosis: Pediatric Sarcoma, Pediatric Oncology

Phase: 3

Protocol Number: 16-721

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

This randomized phase II/III trial studies how well pazopanib hydrochloride, combination chemotherapy, and radiation therapy work and compares it to radiation therapy alone or in combination with p...

Diagnosis: Pediatric Sarcoma

Phase: 2 / 3

Protocol Number: 16-704

Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

The main purpose of this study is to see if using proton beam radiation therapy instead of photon beam radiation therapy can reduce side effects from radiation treatment for rhabdomyosarcoma. Photo...

Diagnosis: Pediatric Sarcoma

Phase: 2

Protocol Number: 04-188

Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors

This research study is studying stereotactic body radiotherapy (SBRT) as a possible treatment for lung relapse of Ewing Sarcoma, Rhabdomyosarcoma, or Wilms Tumor. SBRT is a form of targeted radioth...

Diagnosis: Radiation Oncology, Pediatric Sarcoma

Phase: 1 / 2

Protocol Number: 15-278

A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

This is a Phase I, open-label, dose escalation and dose expansion study with a BID oral dose of tazemetostat. Subjects will be screened for eligibility within 14 days of the planned first dose of t...

Diagnosis: Pediatric Sarcoma

Phase: 1

Protocol Number: 15-467

A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer

The main purpose of this study is to evaluate the safety of different doses of olaratumab and to determine which dose should be used for future pediatric studies. The present study is open to child...

Diagnosis: Pediatric Brain Tumor, Pediatric Solid Tumors, Pediatric Sarcoma, Pediatric Neuroblastoma

Phase: 1

Protocol Number: 16-196

Collecting and Storing Biological Samples From Patients With Ewing Sarcoma

This research study is collecting and storing samples of tumor tissue, bone marrow, and blood from patients with Ewing sarcoma. Collecting and storing samples of tumor tissue, bone marrow, and bloo...

Diagnosis: Pediatric Sarcoma

Phase: N/A

Protocol Number: 08-223

Identification of Biomarkers for Patients With Vascular Anomalies

The study will use participants tissue previously collected and stored in a tissue bank maintained by the Department of Hematology/Oncology as well as tissue banked in the future from participants ...

Diagnosis: Pediatric Solid Tumors, Pediatric Sarcoma


Protocol Number:

PAZIT Study for Children and Young Adults With Relapsed or Refractory Sarcoma

This is the first study to evaluate the safety and clinical activity of the combination of oral pazopanib, intravenous or oral irinotecan, and oral temozolomide in pediatric and young adult patient...

Diagnosis: Pediatric Sarcoma


Protocol Number: 17-199

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are...

Diagnosis: Pediatric Sarcoma, Pediatric Wilms' Tumor


Protocol Number: 17-716