Pediatric Sarcoma Clinical Trials


Displaying all 10 Trial

Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

This randomized phase III trial studies how well combination chemotherapy (vincristine sulfate, dactinomycin, cyclophosphamide alternated with vincristine sulfate and irinotecan hydrochloride) work...

Diagnosis: Pediatric Sarcoma, Pediatric Oncology

Phase: 3

Protocol Number: 16-721

Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

The main purpose of this study is to see if using proton beam radiation therapy instead of photon beam radiation therapy can reduce side effects from radiation treatment for rhabdomyosarcoma. Photo...

Diagnosis: Pediatric Sarcoma

Phase: 2

Protocol Number: 04-188

Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors

This research study is studying stereotactic body radiotherapy (SBRT) as a possible treatment for lung relapse of Ewing Sarcoma, Rhabdomyosarcoma, or Wilms Tumor. SBRT is a form of targeted radioth...

Diagnosis: Radiation Oncology, Pediatric Sarcoma

Phase: 1 / 2

Protocol Number: 15-278

A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

This is a Phase I, open-label, dose escalation and dose expansion study with a BID oral dose of tazemetostat. Subjects will be screened for eligibility within 14 days of the planned first dose of t...

Diagnosis: Pediatric Sarcoma

Phase: 1

Protocol Number: 15-467

Phase I Study of Olaprib and Temozolomide for Ewings Sarcoma

This research study is a Phase I clinical trial, which tests the safety of an investigational drug or combination of drugs and also tries to define the appropriate dose of the combination of invest...

Diagnosis: Sarcoma, Pediatric Sarcoma

Phase: 1

Protocol Number: 13-115

Collecting and Storing Biological Samples From Patients With Ewing Sarcoma

This research study is collecting and storing samples of tumor tissue, bone marrow, and blood from patients with Ewing sarcoma. Collecting and storing samples of tumor tissue, bone marrow, and bloo...

Diagnosis: Pediatric Sarcoma

Phase: N/A

Protocol Number: 08-223

Identification of Biomarkers for Patients With Vascular Anomalies

The study will use participants tissue previously collected and stored in a tissue bank maintained by the Department of Hematology/Oncology as well as tissue banked in the future from participants ...

Diagnosis: Pediatric Solid Tumors, Pediatric Sarcoma


Protocol Number:

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are...

Diagnosis: Pediatric Sarcoma, Pediatric Wilms' Tumor


Protocol Number: 17-716

Clinical Trial of SP-2577 in Patients With Relapsed or Refractory Ewing Sarcoma

Phase 1, open-label, non-randomized dose finding study of SP-2577 in patients with refractory or recurrent Ewing sarcoma.

Diagnosis: Pediatric Sarcoma


Protocol Number: 17-575

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

The overall aim of this study is to determine if epigenetic priming with a DNA methyltransferase inhibitor (DMTi) prior to chemotherapy blocks is tolerable and carries evidence of a clinical effica...

Diagnosis: Pediatric Sarcoma, Pediatric Leukemia


Protocol Number: 18-490