Category:Pediatric
Status:Active
This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia that is likely to come back or sprea...
Diagnosis: Pediatric Leukemia
Phase: 3
Protocol Number: 13-486
The purpose of this study is to determine whether dasatinib is safe and effective in children and adolescents with newly diagnosed chronic myeloid leukemia (CML), or in children with Ph+ acute lymp...
Diagnosis: Pediatric Leukemia, Pediatric Oncology
Phase: 2
Protocol Number: 11-084
This is a pilot study utilizing Marqibo® (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute lymphoblastic leukemia (...
Diagnosis: Pediatric Leukemia
Phase: 1
Protocol Number: 16-568
Matched Targeted Therapy For High-Risk Leukemias
This research study is seeking to gain new knowledge about recurrent, refractory, or high risk leukemias and myelodysplastic syndrome in children and young adults. It is evaluating the use of speci...
Diagnosis: Pediatric Leukemia
Phase: N/A
Protocol Number: 15-384
Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia
This phase III trial studies tretinoin and arsenic trioxide in treating patients with newly diagnosed acute promyelocytic leukemia. Standard treatment for acute promyelocytic leukemia involves high...
Diagnosis: Pediatric Leukemia
Phase:
Protocol Number: 15-719
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents
Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The cancer comes from a cell in the blood called a lymphocyte. Normal lymphocytes are produced in the bone marrow...
Diagnosis: Pediatric Leukemia
Phase:
Protocol Number: 16-001
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laborato...
Diagnosis: Pediatric Lymphoma, Pediatric Leukemia
Phase:
Protocol Number: 16-725
This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome. Drugs used in chemoth...
Diagnosis: Pediatric Leukemia
Phase:
Protocol Number: 16-709
Crizotinib (Xalkori) Expanded Access Protocol For The Treatment Of Adult Or Pediatric Patients
This is an open label expanded access protocol for the treatment of up to approximately 40 adult or pediatric (defined as age <18 years) patients with tumors harboring either a chromosomal trans...
Diagnosis: Pediatric Solid Tumors, Pediatric Leukemia
Phase:
Protocol Number: 16-555
An open-label, global, multi-center study to evaluate the safety and pharmacokinetics of venetoclax monotherapy, to determine the dose limiting toxicity (DLT) and the recommended Phase 2 dose (RPTD...
Diagnosis: Pediatric Leukemia, Pediatric Solid Tumors, Pediatric Lymphoma
Phase:
Protocol Number: 17-617
A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia
This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optim...
Diagnosis: Pediatric Hematology/Blood Related, Pediatric Leukemia
Phase:
Protocol Number: 17-290
Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia
This phase II trial studies how well trametinib works in treating patients with juvenile myelomonocytic leukemia that has come back or does not respond to treatment. Trametinib may stop the growth ...
Diagnosis: Pediatric Leukemia, Pediatric Hematology/Blood Related
Phase:
Protocol Number: 18-712
Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer
This research study is studying a novel drug called ALRN-6924 as a possible treatment for resistant (refractory) solid tumor, brain tumor, lymphoma or leukemia. The drugs involved in this study are...
Diagnosis: Pediatric Leukemia, Pediatric Brain Tumor, Pediatric Lymphoma, Pediatric Solid Tumors
Phase:
Protocol Number: 18-284
A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia
The overall aim of this study is to determine if epigenetic priming with a DNA methyltransferase inhibitor (DMTi) prior to chemotherapy blocks is tolerable and carries evidence of a clinical effica...
Diagnosis: Pediatric Sarcoma, Pediatric Leukemia
Phase:
Protocol Number: 18-490