Pediatric Leukemia Clinical Trials


Displaying all 14 Trial

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia that is likely to come back or sprea...

Diagnosis: Pediatric Leukemia

Phase: 3

Protocol Number: 13-486

A Phase II Study of Dasatinib in Children and Adolescents With Newly Diagnosed Chronic Phase CML or With Ph+ Leukemias Resistant or Intolerant to Imatinib

The purpose of this study is to determine whether dasatinib is safe and effective in children and adolescents with newly diagnosed chronic myeloid leukemia (CML), or in children with Ph+ acute lymp...

Diagnosis: Pediatric Leukemia, Pediatric Oncology

Phase: 2

Protocol Number: 11-084

Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL

This is a pilot study utilizing Marqibo® (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute lymphoblastic leukemia (...

Diagnosis: Pediatric Leukemia

Phase: 1

Protocol Number: 16-568

Matched Targeted Therapy For High-Risk Leukemias

This research study is seeking to gain new knowledge about recurrent, refractory, or high risk leukemias and myelodysplastic syndrome in children and young adults. It is evaluating the use of speci...

Diagnosis: Pediatric Leukemia

Phase: N/A

Protocol Number: 15-384

Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia

This phase III trial studies tretinoin and arsenic trioxide in treating patients with newly diagnosed acute promyelocytic leukemia. Standard treatment for acute promyelocytic leukemia involves high...

Diagnosis: Pediatric Leukemia


Protocol Number: 15-719

Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The cancer comes from a cell in the blood called a lymphocyte. Normal lymphocytes are produced in the bone marrow...

Diagnosis: Pediatric Leukemia


Protocol Number: 16-001

Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laborato...

Diagnosis: Pediatric Lymphoma, Pediatric Leukemia


Protocol Number: 16-725

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome. Drugs used in chemoth...

Diagnosis: Pediatric Leukemia


Protocol Number: 16-709

Crizotinib (Xalkori) Expanded Access Protocol For The Treatment Of Adult Or Pediatric Patients

This is an open label expanded access protocol for the treatment of up to approximately 40 adult or pediatric (defined as age <18 years) patients with tumors harboring either a chromosomal trans...

Diagnosis: Pediatric Solid Tumors, Pediatric Leukemia


Protocol Number: 16-555

A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies

An open-label, global, multi-center study to evaluate the safety and pharmacokinetics of venetoclax monotherapy, to determine the dose limiting toxicity (DLT) and the recommended Phase 2 dose (RPTD...

Diagnosis: Pediatric Leukemia, Pediatric Solid Tumors, Pediatric Lymphoma


Protocol Number: 17-617

A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optim...

Diagnosis: Pediatric Hematology/Blood Related, Pediatric Leukemia


Protocol Number: 17-290

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

This phase II trial studies how well trametinib works in treating patients with juvenile myelomonocytic leukemia that has come back or does not respond to treatment. Trametinib may stop the growth ...

Diagnosis: Pediatric Leukemia, Pediatric Hematology/Blood Related


Protocol Number: 18-712

Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer

This research study is studying a novel drug called ALRN-6924 as a possible treatment for resistant (refractory) solid tumor, brain tumor, lymphoma or leukemia. The drugs involved in this study are...

Diagnosis: Pediatric Leukemia, Pediatric Brain Tumor, Pediatric Lymphoma, Pediatric Solid Tumors


Protocol Number: 18-284

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

The overall aim of this study is to determine if epigenetic priming with a DNA methyltransferase inhibitor (DMTi) prior to chemotherapy blocks is tolerable and carries evidence of a clinical effica...

Diagnosis: Pediatric Sarcoma, Pediatric Leukemia


Protocol Number: 18-490