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Colorectal Cancer Clinical Trials

Category:Adult
Status:Active

Displaying all 12 trials

PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery

The standard treatment for locally advanced rectal cancer involves chemotherapy and radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation therapy) prior to s...

Diagnosis: Colorectal Cancer, Gastrointestinal Malignancies

Phase: 2 / 3

Protocol Number: 12-023

Phase II Trial of Irinotecan, Cetuximab, and Bevacizumab Compared With Irinotecan, Cetuximab, and Placebo in KRAS-Wildtype, Irinotecan-Refractory, Metastatic Colorectal Cancer

The purpose of this research study is to see if cancer will respond better to a combination of irinotecan and cetuximab with or without bevacizumab

Diagnosis: Gastrointestinal Malignancies, Colorectal Cancer

Phase: 2

Protocol Number: 14-574

Safety and Efficacy of FGF401 in Patients With Solid Malignancies

Estimate the maximum tolerated dose and/or recommended phase two dose and efficacy of FGF401 on patients with solid malignancies

Diagnosis: Gastrointestinal Malignancies, Stomach Cancer, Liver Cancer, Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer

Phase: 1 / 2

Protocol Number: 14-464

Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma

The primary goal of this Phase 1 study is to characterize the safety and tolerability of MGD007 and establish the maximum tolerated dose (MTD) of MGD007 administered on either weekly or every three...

Diagnosis: Gastrointestinal Malignancies, Colorectal Cancer

Phase: 1

Protocol Number: 14-524

A Study of AbGn-107 in Patients With Gastric, Colorectal, or Pancreatic Cancer

This study is to define the safety profile and to determine the maximum tolerated dose (MTD) and preliminary efficacy of AbGn-107 administered every 28 days (4 weeks) in patients with chemo-refract...

Diagnosis: Gastrointestinal Malignancies, Pancreatic Cancer, Colorectal Cancer

Phase: 1

Protocol Number: 17-137

Study to Identify Transcriptional Targets of Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases Receiving Preoperative Vitamin D Supplementation.

This study seeks to learn more about the vitamin D receptor and its relationship to colon cancer. The Vitamin D receptor is found in colon cancer cells. When Vitamin D binds to the receptor in the ...

Diagnosis: Gastrointestinal Malignancies, Colorectal Cancer

Phase: 0

Protocol Number: 14-091

Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using...

Diagnosis: Colorectal Cancer, Esophageal Cancer, Gastrointestinal Malignancies, Pancreatic Cancer

Phase: N/A

Protocol Number: 13-415

Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer

This research study is studying a combination of drugs with radiation therapy as a possible treatment for Microsatellite Stable Colorectal Cancer, Pancreatic Cancer, or MSI High Colorectal Cancer. ...

Diagnosis: Colorectal Cancer, Pancreatic Cancer

Phase:

Protocol Number: 17-021

Safety and Efficacy Study of AMG 820 and Pembrolizumab Combination in Select Advanced Solid Tumor Cancer

A multi-center Phase 1b/2 study testing the combination of AMG 820 and pembrolizumab in subjects with select advanced solid tumors.

Diagnosis: Pancreatic Cancer, Gastrointestinal Malignancies, Lung Cancer, Colorectal Cancer

Phase:

Protocol Number: 16-502

A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10

This is an open-label Phase 1a/b dose-escalation study to assess the safety, tolerability, and PK of OMP-131R10 as a single agent for advanced solid tumors and in subjects with metastatic colorecta...

Diagnosis: Gastrointestinal Malignancies, Colorectal Cancer

Phase:

Protocol Number: 17-197

Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V

This is a multicenter, randomized, open-label, 3-arm Phase 3 study to evaluate encorafenib + cetuximab plus or minus binimetinib versus Investigator's choice of either irinotecan/cetuximab or F...

Diagnosis: Colorectal Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 17-124

Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer

This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer. The interventions involved in this study are: - T...

Diagnosis: Colorectal Cancer, Liver Cancer, Gastrointestinal Malignancies

Phase:

Protocol Number: 17-231

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