Header

Brain/Neuro Cancer: Newly Diagnosed Clinical Trials

Category:Adult
Status:Active

Displaying all 16 trials

Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma

The purpose of this study is to find out what effects (good and/or bad) treatment with chemotherapy and stem cell transplant compared with chemotherapy alone will have on primary CNS B-cell lymphom...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 12-440

Carboplatin and Bevacizumab for Recurrent Ependymoma

The goal of this clinical research study is to learn if the combination of bevacizumab and carboplatin can help to control recurrent pendymoma. The safety of this drug combination will also be stud...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 13-249

Phase 2 Study of MEDI4736 in Patients With Glioblastoma

This is an open-label, non-randomized, multicenter Phase 2 study of MEDI4736 with three non-comparative cohorts: Cohort A: 37 subjects with newly diagnosed unmethylated MGMT GBM will receive MEDI47...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 14-412

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation thera...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 15-708

TH-302 in Combination With Bevacizumab for Glioblastoma

Dual center, single arm, two-stage, non-blinded, prospective study of combination therapy bevacizumab at 10mg/kg and TH-302 at 670mg/m2 every 2 weeks (6 week cycle) until disease progression.

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 15-104

A Study Looking at Targeted Therapy According to Tumor Markers for People With Meningiomas

This phase II trial studies how well vismodegib and focal adhesion kinase (FAK) inhibitor GSK2256098 work in treating patients with meningiomas that may have gotten bigger or grew back after treatm...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 15-715

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This phase II trial studies the side effects and how well vaccine therapy works when given together with temozolomide in treating patients with newly diagnosed glioblastoma. Vaccines made from the ...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 16-138

A Study of Galunisertib (LY2157299) in Combination With Nivolumab in Advanced Refractory Solid Tumors and in Recurrent or Refractory NSCLC, Hepatocellular Carcinoma, or Glioblastoma

The main purpose of this study is to evaluate the safety, tolerability, and efficacy of the study drug known as galunisertib in combination with nivolumab in participants with advanced refractory s...

Diagnosis: Solid Tumor/Phase I, Lung Cancer, Brain/Neuro Cancer: Newly Diagnosed

Phase: 1 / 2

Protocol Number: 15-557

A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy

This research study is studying the changes in primary and metastatic brain tumor inflammation using positron emission tomography (PET) imaging using a radioactive substance called [11C] PBR28a, wh...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: N/A

Protocol Number: 14-421

Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRI

This research study aims to predict treatment response to anti-angiogenic therapy (Avastin) using advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) for Glioblastoma patients.

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: N/A

Protocol Number: 16-147

Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation

This study evaluates the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in advanced solid tumors, including gliomas, that harbor an IDH1 and/or IDH2 mutation.

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 15-268

A Study of ABT-414 in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification

This study seeks to determine whether the addition of ABT-414 to concomitant radiotherapy and temozolomide (TMZ) prolongs progression free survival (PFS) and overall survival (OS) in participants w...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 15-554

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : - Abemaciclib - Temozolomide (temodar) - Neratin...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 16-443

An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)

The purpose of this study is to evaluate patients with glioblastoma that is MGMT-unmethylated (the MGMT gene is not altered by a chemical change). Patients will receive Nivolumab every two weeks in...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 16-552

An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)

The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by a chemical change). Patients will receive temozolomide plus radiation therap...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 16-551

Bavituximab With Radiation and Temozolomide for Patients With Newly Diagnosed Glioblastoma

This research study is studying a combination of drugs with radiation as a possible treatment for Glioblastoma. The drugs involved in this study are: - Bavituximab - Temozolomide

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 17-037

'