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Brain/Neuro Cancer: Newly Diagnosed Clinical Trials

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Displaying all 15 Trial

Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma

The purpose of this study is to find out what effects (good and/or bad) treatment with chemotherapy and stem cell transplant compared with chemotherapy alone will have on primary CNS B-cell lymphom...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 12-440

Carboplatin and Bevacizumab for Recurrent Ependymoma

The goal of this clinical research study is to learn if the combination of bevacizumab and carboplatin can help to control recurrent pendymoma. The safety of this drug combination will also be stud...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 13-249

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation thera...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: 2

Protocol Number: 15-708

A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy

This research study is studying the changes in primary and metastatic brain tumor inflammation using positron emission tomography (PET) imaging using a radioactive substance called [11C] PBR28a, wh...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: N/A

Protocol Number: 14-421

Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRI

This research study aims to predict treatment response to anti-angiogenic therapy (Avastin) using advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) for Glioblastoma patients.

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase: N/A

Protocol Number: 16-147

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : - Abemaciclib - Temozolomide (temodar) - Neratin...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 16-443

An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)

The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by a chemical change). Patients will receive temozolomide plus radiation therap...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 16-551

Avelumab With Hypofractionated Radiation Therapy in Adults With Isocitrate Dehydrogenase (IDH) Mutant Glioblastoma

The purpose of this study is to test how safe and effective treatment with the combination of Avelumab and radiation is for IDH mutant gliomas that have transformed to glioblastoma after chemotherapy.

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 17-309

MDM2 Inhibitor AMG-232 in Treating Patients With Recurrent or Newly Diagnosed Glioblastoma

This phase 0/I trial studies the side effects and best dose of MDM2 inhibitor AMG-232 in treating patients with glioblastoma that is newly diagnosed or has come back. MDM2 inhibitor AMG-232 may sto...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 17-453

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This ...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed, Radiation Oncology

Phase:

Protocol Number: 18-018

Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects

The purpose of this study is to assess the safety and tolerability of VBI-1901 in subjects with Recurrent GBM.

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 18-156

Pembrolizumab and Reirradiation in Bevacizumab Naïve and Bevacizumab Resistant Recurrent Glioblastoma

This research study is studying pembrolizumab and re-irradiation as possible treatments for glioblastoma. The drugs involved in this study are: - Pembrolizumab - Radiation - Bevacizumab, an FDA-app...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 18-277

GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas

The purpose of this phase I trial is to test the safety of combining GMCI, an immunostimulator, plus nivolumab, an immune checkpoint inhibitor (ICI), with standard of care radiation therapy, and te...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 17-655

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

Phase 1/2 trial to evaluate safety, immunogenicity and preliminary efficacy of INO-5401 and INO-9012 in combination with cemiplimab (REGN2810), with radiation and chemotherapy, in subjects with new...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 18-377

Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption

The purpose of this study is to evaluate the safety of the ExAblate Model 4000 Type 2.0 used as a tool to disrupt the BBB (blood brain barrier) in patients with high grade glioma undergoing standar...

Diagnosis: Brain/Neuro Cancer: Newly Diagnosed

Phase:

Protocol Number: 18-484

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