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Brain/Neuro Cancer: Recurrent Glioblastoma Clinical Trials

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Displaying all 15 Trial

FMISO PET Study of Glioblastoma

In this research study, the investigators are using FMISO-PET and MRI scans to explore the delivery of bevacizumab to the blood vessels in patient's with recurrent glioblastoma before and afte...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 2

Protocol Number: 13-482

Oral ONC201 in Adult Recurrent Glioblastoma

ONC201 is a new drug candidate that kills cancer cells but not normal cells in laboratory studies and successfully completed a phase I clinical trial in advanced cancer patients. This clinical tria...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 2

Protocol Number: 15-318

Anti-LAG-3 or Urelumab Alone and in Combination With Nivolumab in Treating Patients With Recurrent Glioblastoma

This phase I trial studies the safety and best dose of anti-LAG-3 (anti-LAG-3 monoclonal antibody BMS-986016) or urelumab alone and in combination with nivolumab in treating patients with glioblast...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 1

Protocol Number: 16-016

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

This research study involves two investigational drugs, veledimex, an activator ligand (INXN-1001) in combination with an Adenovirus Vector Engineered to Express hIL-12 (INXN-2001). IL-12 is a prot...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 14-339

A Study of Abemaciclib in Recurrent Glioblastoma

This research study is studying a targeted therapy as a possible treatment for recurrent glioblastoma (GBM). The following intervention will be used in this study: -Abemaciclib

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 16-383

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

This pilot clinical trial studies how well lapatinib ditosylate before surgery works in treating patients with high-grade glioma that has come back after a period of time during which the tumor cou...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 14-297

HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma

This phase II trial studies how well HIF-2 alpha inhibitor PT2385 works in treating patients with recurrent glioblastoma. HIF-2 alpha inhibitor PT2385 may stop the growth of tumor cells by blocking...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 17-277

Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma

This randomized phase II trial studies how well cediranib maleate and olaparib work compared to bevacizumab in treating patients with glioblastoma that has come back. Cediranib maleate and olaparib...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 17-735

A Study Assessing BGB-290 With Radiation and/or Temozolomide (TMZ) in Subjects With Newly Diagnosed or Recurrent Glioblastoma

This study is to evaluate the safety, efficacy and clinical activity of BGB-290 in combination with radiation therapy (RT) and/or temozolomide (TMZ) in subjects with newly diagnosed or recurrent/re...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 17-435

A Study of Ad-RTS-hIL-12 With Veledimex in Combination With Nivolumab in Subjects With Glioblastoma; a Substudy to ATI001-102

This research study involves an investigational product: Ad-RTS-hIL-12 given with veledimex for production of human IL-12. IL-12 is a protein that can improve the body's natural response to di...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 18-209

Mathematical Model-Adapted Radiation In Glioblastoma

This research study is studying a new schedule of radiation therapy for recurrent glioblastoma as a possible treatment for this diagnosis. This radiation schedule is based on a new model for radiat...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 18-105

Study to Evaluate Ibudilast and TMZ Combo Treatment in Recurrent GBM

Part 1 is an open-label, single-arm, dose escalation study of MN-166 (ibudilast) and temozolomide (TMZ) combination treatment. Evaluate safety and tolerability of ibudilast (MN-166) and TMZ combina...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 18-436

Nivolumab Plus Standard Dose Bevacizumab Versus Nivolumab Plus Low Dose Bevacizumab in GBM

The purpose of this study is to test the effectiveness (how well the drug works), safety and tolerability of an investigational drug called nivolumab (also known as BMS-936558) in glioblastoma (a m...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 18-298

Safety, Preliminary Efficacy and PK of Isatuximab (SAR650984) Alone or in Combination With Atezolizumab in Patients With Advanced Malignancies

Primary Objectives: - Phase1: To characterize the safety and tolerability of isatuximab in combination with atezolizumab in participants with unresectable hepatocellular carcinoma (HCC), platinum-r...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma, Head and Neck Cancer, GYN: Ovarian, Fallopian, Peritoneal Cancer, Liver Cancer

Phase:

Protocol Number: 18-332

Feasibility of the LUM Imaging System for Detection of Cancer to the Brain

The overall objective of this study is to assess the safety and efficacy of the LUM Imaging System in imaging primary and metastatic cancer in the brain. This includes selecting a dose to determine...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 18-463

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