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Brain/Neuro Cancer: Recurrent Glioblastoma Clinical Trials

Category:Adult
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Displaying all 11 trials

FMISO PET Study of Glioblastoma

In this research study, the investigators are using FMISO-PET and MRI scans to explore the delivery of bevacizumab to the blood vessels in patient's with recurrent glioblastoma before and after...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 2

Protocol Number: 13-482

Phase 2 Study of Selinexor (KPT-330) in Patients With Recurrent Glioblastoma or Other Brain Cancers After Failure of Radiation and Temozolomide

This is an open-label, multicenter, Phase 2 study to evaluate the efficacy and safety of oral Selinexor in patients with recurrent gliomas.

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 2

Protocol Number: 14-029

Oral ONC201 in Adult Recurrent Glioblastoma

ONC201 is a new drug candidate that kills cancer cells but not normal cells in laboratory studies and successfully completed a phase I clinical trial in advanced cancer patients. This clinical tria...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 2

Protocol Number: 15-318

Anti-LAG-3 or Urelumab Alone and in Combination With Nivolumab in Treating Patients With Recurrent Glioblastoma

This phase I trial studies the safety and best dose of anti-LAG-3 (anti-LAG-3 monoclonal antibody BMS-986016) or urelumab alone and in combination with nivolumab in treating patients with glioblast...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: 1

Protocol Number: 16-016

TORC1/2 Inhibitor INK128 Before and After Surgery in Treating Patients With Recurrent Glioblastoma

This partially randomized pilot trial studies how much TORC1/2 inhibitor INK128 reaches the brain tumor and how well it works when given before and after surgery in treating patients with glioblast...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase: N/A

Protocol Number: 14-095

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

This research study involves two investigational drugs, veledimex, an activator ligand (INXN-1001) in combination with an Adenovirus Vector Engineered to Express hIL-12 (INXN-2001). IL-12 is a prot...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 14-339

A Study of Abemaciclib in Recurrent Glioblastoma

This research study is studying a targeted therapy as a possible treatment for recurrent glioblastoma (GBM). The following intervention will be used in this study: -Abemaciclib

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 16-383

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

This pilot clinical trial studies how well lapatinib ditosylate before surgery works in treating patients with high-grade glioma that has come back after a period of time during which the tumor cou...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 14-297

HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma

This phase II trial studies how well HIF-2 alpha inhibitor PT2385 works in treating patients with recurrent glioblastoma. HIF-2 alpha inhibitor PT2385 may stop the growth of tumor cells by blocking...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 17-277

Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma

This randomized phase II trial studies how well cediranib maleate and olaparib work compared to bevacizumab in treating patients with glioblastoma that has come back. Cediranib maleate and olaparib...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 17-735

A Study Assessing BGB-290 With Radiation and/or Temozolomide (TMZ) in Subjects With Newly Diagnosed or Recurrent Glioblastoma

This study is to evaluate the safety, efficacy and clinical activity of BGB-290 in combination with radiation therapy (RT) and/or temozolomide (TMZ) in subjects with newly diagnosed or recurrent/re...

Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma

Phase:

Protocol Number: 17-435

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