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Pediatric Hematopoietic Stem Cell Transplant (HSCT) Clinical Trials

Category:Pediatric
Status:Active

Displaying all 9 trials

A Phase 2/3 Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Childhood Cerebral Adrenoleukodystrophy (CCALD)

This trial will assess the efficacy and safety of autologous CD34+ hematopoietic stem cells, transduced ex-vivo with Lenti-D lentiviral vector, for the treatment of childhood cerebral adrenoleukody...

Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT)

Phase: 2 / 3

Protocol Number:

Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita

Dyskeratosis congenita is a disease that affects numerous parts of the body, most typically causing failure of the blood system. Lung disease and a predisposition to cancer are also frequent causes...

Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT)

Phase: 2

Protocol Number: 16-294

Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes

This randomized phase II trial studies how well donor umbilical cord blood transplant with or without ex-vivo expanded cord blood progenitor cells works in treating patients with acute myeloid leuk...

Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT), Pediatric Leukemia

Phase: 2

Protocol Number: 13-042

Abatacept as GVHD Prophylaxis Phase 2

This is a phase II multi-center, randomized, double blind, placebo-controlled trial. The investigators are doing this study to see if a new drug, abatacept, can be used together with a calcineurin ...

Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT)

Phase: 2

Protocol Number: 14-327

Gut Decontamination In Pediatric Allogeneic Hematopoietic

This research study is for participants who are undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and are at risk for developing acute graft-versus-host disease (GVHD). GVHD is a...

Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT)

Phase: 2

Protocol Number: 15-394

Pilot and Feasibility Study of Hematopoietic Stem Cell Gene Transfer for the Wiskott-Aldrich Syndrome

The Wiskott-Aldrich Syndrome (WAS) is an inherited disorder that results in defects of the blood and bone marrow. It affects boys because the genetic mistake is carried on the X chromosome. Normal ...

Diagnosis: Pediatric Hematology/Blood Related, Pediatric Hematopoietic Stem Cell Transplant (HSCT)

Phase: 1 / 2

Protocol Number:

Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector

Researchers are working on ways to treat SCID patients who don't have a matched brother or sister. One of the goals is to avoid the problems that happen with stem cell transplant from parents a...

Diagnosis: Pediatric Hematology/Blood Related, Pediatric Hematopoietic Stem Cell Transplant (HSCT)

Phase: 1 / 2

Protocol Number:

Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease

Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency disorder which results from defects that prevent white blood cells from effectively killing bacteria, fungi and other microorgan...

Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT), Pediatric Hematology/Blood Related

Phase: 1 / 2

Protocol Number:

Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia

The purpose of this study is to determine the feasibility of comparing outcomes of patients treated de novo with immunosuppressive therapy (IST) versus matched unrelated donor (MUD) hematopoietic s...

Diagnosis: Pediatric Hematology/Blood Related, Pediatric Hematopoietic Stem Cell Transplant (HSCT)

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Protocol Number:

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