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Breast: Early Stage Disease Clinical Trials

Category:Adult
Status:Active

Displaying trials 1 - 30 of 38 in total

Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energ...

Diagnosis: Breast: Early Stage Disease

Phase: 3

Protocol Number: 13-504

Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer

Olaparib treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy

Diagnosis: Breast: Early Stage Disease

Phase: 3

Protocol Number: 15-009

PALbociclib CoLlaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2

This is a prospective, two arm, international, multicenter, randomized, open-label Phase III study evaluating the addition of 2 years of palbociclib to standard adjuvant endocrine therapy for patie...

Diagnosis: Breast: Early Stage Disease

Phase: 3

Protocol Number: 15-488

Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

A pragmatic randomized clinical trial of patients with locally advanced breast cancer randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity and mort...

Diagnosis: Breast: Early Stage Disease

Phase: 3

Protocol Number: 16-188

Breast Cancer WEight Loss Study (BWEL Study)

This randomized phase III trial studies whether weight loss in overweight and obese women may prevent breast cancer from coming back (recurrence). Previous studies have found that women who are ove...

Diagnosis: Breast: Early Stage Disease

Phase: 3

Protocol Number: 16-716

Aspirin in Preventing Recurrence of Cancer in Patients With Node Positive Triple Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

This randomized phase III trial studies how well aspirin works in preventing the cancer from coming back (recurrence) in patients with human epidermal growth factor receptor 2 (HER2) breast cancer ...

Diagnosis: Lung Cancer, Breast: Early Stage Disease

Phase: 3

Protocol Number: 16-727

PhII Neo-Adjuvant Letrozole & Lapatinib in Pts w/HER2+ & Hormone Receptor+ Operable Breast CA SPORE

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the amount of estrogen the body makes. Lapatinib may stop the gr...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 08-165

Cisplatin vs. Doxorubicin/Cyclophosphamide in BrCa

This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug, which is cisplatin in this trial, to learn how well it works in treatin...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 12-258

Cisplatin vs Paclitaxel for Triple Neg

This research study is evaluating how well triple negative breast cancer responds to preoperative treatment with Cisplatin or Paclitaxel chemotherapy, and if use of a research test Homologous Recom...

Diagnosis: Breast: Metastatic, Breast: Early Stage Disease

Phase: 2

Protocol Number: 13-383

Evaluating Mass Spectrometry And Intraoperative MRI In The Advanced Multimodality Image Guided Operating Suite (Amigo) In Breast-Conserving Therapy

The purpose of this study is to investigate the use of intra-operative Magnetic Resonance Imaging (MRI) and Mass Spectrometry (MS) during breast conserving surgery, and to determine if these tests ...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 14-476

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

This research study is studying a combination of drugs as a possible treatment for breast cancer that has tested positive for a protein called HER2. The names of the study interventions involved in...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 14-409

A Phase 2 Study of Eribulin Followed by AC as Preoperative Therapy for HER2-negative Inflammatory Breast Cancer

This research study is studying a drug called eribulin combined with standard treatment as a possible preoperative treatment for HER2 negative inflammatory breast cancer.

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 15-292

The PRECISION Trial (Profiling Early Breast Cancer for Radiotherapy Omission): A Phase II Study of Breast-Conserving Surgery Without Adjuvant Radiotherapy for Favorable-Risk Breast Cancer

This research study is a way of gaining new knowledge about whether patients can omit radiation treatment after undergoing a lumpectomy, also known as "breast conserving surgery". In this...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 15-255

Avoiding Growth Factor During Paclitaxel Treatment in Breast Cancer

This research study is testing the safety and feasibility of delivering the 4 cycles of 'dose-dense' paclitaxel without the use of Neulasta (Pegfilgrastim) as a Granulocyte Colony-stimulati...

Diagnosis: Breast: Metastatic, Breast: Early Stage Disease

Phase: 2

Protocol Number: 15-516

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)

This research study is evaluating how well Breast Cancer responds to preoperative treatment with Endocrine treatment in combination with a drug called Palbociclib or Endocrine treatment alone as po...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 16-052

Letrozole Plus Ribociclib or Placebo as Neo-adjuvant Therapy in ER-positive, HER2-negative Early Breast Cancer

The purpose of this study is to determine if ribociclib in combination with letrozole for 24 weeks as neoadjuvant endocrine therapy increases the proportion of women with Pre-operative Endocrine Pr...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 16-195

Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer

This research study is studying Ruxolitinib as possible treatment for Inflammatory Breast Cancer (IBC). The Following drugs will be use in combination with Ruxolinitinib. - Paclitaxel (also called ...

Diagnosis: Breast: Early Stage Disease

Phase: 2

Protocol Number: 16-151

Cisplatin + RT for Triple Negative Breast Cancer

This is a Phase I dose escalation study of cisplatin and concurrent radiation in patients with ER negative, PR negative and HER2 negative breast cancer who have undergone breast-conserving surgery ...

Diagnosis: Breast: Early Stage Disease

Phase: 1

Protocol Number: 12-283

Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer

This research study is a way of gaining new knowledge about the combination of Taselisib with other drugs in the treatment of metastatic breast cancer. Taselisib is an investigational drug which wo...

Diagnosis: Breast: Early Stage Disease

Phase: 1

Protocol Number: 15-024

Adjuvant PVX-410 Vaccine and Durvalumab in Stage II/III Triple Negative Breast Cancer

The purpose of this research study is to evaluate Immunotherapy with a peptide vaccine and Programmed Death Ligand 1 (PD-L1) inhibitor as a possible adjuvant treatment for Stage II or III Triple Ne...

Diagnosis: Breast: Early Stage Disease

Phase: 1

Protocol Number: 16-132

Comparison of Contrast-enhanced Spectral Mammography (CESM) to MRI in Screening High Risk Women for Breast Cancer

This research study is comparing Dual-Energy Contrast-Enhanced Spectral Mammography (CESM) to MRI as a screening tool for breast cancer.

Diagnosis: Breast: Early Stage Disease

Phase: N/A

Protocol Number: 14-225

The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy

This research study is studying a surgical intervention to rule out the presence of cancer in participants that have been diagnosed with flat epithelial atypia (FEA) or intraductal papilloma withou...

Diagnosis: Breast: Early Stage Disease

Phase: N/A

Protocol Number: 15-174

Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer

The best available evidence suggests that pregnancy after breast cancer does not increase a woman's risk of developing a recurrence from her breast cancer. In particular, the most recent data s...

Diagnosis: Breast: Early Stage Disease

Phase: N/A

Protocol Number:

Pilot Study of a Pharmacy Intervention for Older Adults With Cancer

The purpose of this research study is to address the challenge of medication management for older patients undergoing treatment for cancer. The sponsor of this protocol is the Massachusetts General...

Diagnosis: Breast: Early Stage Disease, Lung Cancer, Gastrointestinal Malignancies

Phase: N/A

Protocol Number: 16-230

A Breast Cancer Treatment Decision Aid for Women Aged 70 and Older

The purpose of this research study is to evaluate a decision aid to help women aged 70 and older decide on treatment for their breast cancer.

Diagnosis: Breast: Early Stage Disease

Phase: N/A

Protocol Number: 16-117

Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy

This research is studying a new investigative imaging instrument called a nonlinear microscope (NLM). A nonlinear microscope can produce images similar to an ordinary pathologist's microscope, ...

Diagnosis: Breast: Early Stage Disease

Phase: N/A

Protocol Number: 16-145

Comparison of Operative to Medical Endocrine Therapy (COMET) Trial For Low Risk DCIS

This study looks at the risks and benefits of active surveillance (AS) compared to guideline concordant care (GCC) in the setting of a pragmatic prospective randomized trial for low risk DCIS. Our ...

Diagnosis: Breast: Early Stage Disease

Phase: N/A

Protocol Number: 17-131

The IDEA Study (Individualized Decisions for Endocrine Therapy Alone)

This study will collect rates of local/regional recurrence in select patients who do not receive radiation treatment after lumpectomy surgery. These women must be postmenopausal; have hormone recep...

Diagnosis: Breast: Early Stage Disease

Phase:

Protocol Number: 15-184

Supine MRI in Breast Cancer Patients Receiving Neoadjuvant Therapy

This research study involves the use of a common breast imaging modality (magnetic resonance imaging, 'MRI') and is investigating its role in evaluating treatment for breast cancer when it ...

Diagnosis: Breast: Early Stage Disease

Phase:

Protocol Number: 16-277

A Study of PDR001 in Combination With LCL161, Everolimus or Panobinostat

The purpose of this study is to combine the PDR001 checkpoint inhibitor with several agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to prelimin...

Diagnosis: Breast: Early Stage Disease

Phase:

Protocol Number: 16-423

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