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Head and Neck Cancer Clinical Trials

Category:Adult
Status:Active

Displaying all 25 trials

Randomized Trial of Intensity-Modulated Proton Beam Therapy (IMPT) Versus Intensity-Modulated Photon Therapy (IMRT) for the Treatment of Oropharyngeal Cancer of the Head and Neck

The goal of this clinical research study is to compare the side effects of 2 radiation treatments for head and neck cancer. The 2 treatments are intensity modulated photon therapy (IMRT) and intens...

Diagnosis: Head and Neck Cancer, Radiation Oncology

Phase: 2 / 3

Protocol Number: 16-155

Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations

Phase II study to investigate the antitumor activity in terms of ORR of tipifarnib in subjects with advanced tumors that carry HRAS mutations and for whom there is no standard curative therapy avai...

Diagnosis: Head and Neck Cancer

Phase: 2

Protocol Number: 15-106

Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer

This randomized phase II trial studies how well iodine I-131works with or without selumetinib in treating patients with thyroid cancer that has returned or has spread from where it started to other...

Diagnosis: Head and Neck Cancer

Phase: 2

Protocol Number:

A Phase II Study of MLN0128 in Metastatic Anaplastic Thyroid Cancer

This research study is studying a targeted therapy (ML0N128) as a possible treatment for anaplastic thyroid cancer. This research study is a Phase II clinical trial. Phase II clinical trials test t...

Diagnosis: Head and Neck Cancer

Phase: 2

Protocol Number: 14-223

A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer

This research study is studying a targeted therapy as a possible treatment for thyroid cancer. A targeted therapy is a type of treatment that uses drugs or other substances to identify and attack s...

Diagnosis: Head and Neck Cancer

Phase: 2

Protocol Number: 15-350

Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity

This research study is studying nivolumab, an investigational drug, in combination with ipilimumab, also an investigational drug, as a possible treatment for Squamous Cell Carcinoma of the oral cav...

Diagnosis: Head and Neck Cancer

Phase: 2

Protocol Number: 16-284

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

The goal of this trial is to test the ability of MK-3475 (pembrolizumab) to improve locoregional recurrence and distant metastatic rates in high-risk patients with locally advanced head and neck sq...

Diagnosis: Head and Neck Cancer

Phase: 2

Protocol Number: 16-385

MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma

This research study is studying a targeted therapy as a possible treatment for merkel cell carcinoma. - The name of the study intervention involved in this study is: MLN0128.

Diagnosis: Head and Neck Cancer

Phase: 1 / 2

Protocol Number: 15-223

Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer

This research study is studying a vaccine, named DPX-E7, as a possible treatment for Human Papilloma Virus or HPV related head and neck, cervical or anal cancer (positive for HLA-A*02).

Diagnosis: Head and Neck Cancer

Phase: 1 / 2

Protocol Number: 15-578

Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer

This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational drug. Phase I studies also try to define the appropriate dose of the investigational d...

Diagnosis: Head and Neck Cancer

Phase: 1

Protocol Number: 12-267

Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck

This research study is evaluating a drug called buparlisib (BKM120) as a possible treatment for locally advanced head and neck squamous cell cancer.

Diagnosis: Head and Neck Cancer

Phase: 1

Protocol Number: 14-008

Study Evaluating a Stereotactic Boost/Treatment for Recurrent or Metastatic Cancer of the Head and Neck

This research study seeks to gain new knowledge about the addition of a carefully targeted "boost" dose of radiation as a possible treatment for recurrent or metastatic head or neck cance...

Diagnosis: Head and Neck Cancer, Radiation Oncology

Phase: 1

Protocol Number: 15-183

In-Room PET in Proton Radiation Therapy

The investigational part of this study is using a mobile PET/CT scanner to take images of the participants tumor immediately after they are treated with proton radiation. This allows the participan...

Diagnosis: Brain/Neuro Cancer: Supportative Care, Head and Neck Cancer

Phase: 0

Protocol Number: 10-241

Image-guided Cryoablation of Head, Neck and Spine Tumors

This research study is evaluating a procedure called cryoablation (the removal of diseased tissue using extreme freezing temperatures) as a possible treatment for head, neck and spine tumors.

Diagnosis: Head and Neck Cancer

Phase: N/A

Protocol Number: 13-458

A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)

This is a Phase 1/2, open label study that will be conducted in 2 parts. The first part of the study (Phase 1) will consist of a dose-escalation assessment of the safety and tolerability of epacado...

Diagnosis: Head and Neck Cancer, Brain/Neuro Cancer: Recurrent Glioblastoma, Lung Cancer, GYN: Ovarian, Fallopian, Peritoneal Cancer

Phase:

Protocol Number: 15-484

A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC)

The primary purpose of the study is to evaluate objective response rate ([ORR]: complete response [CR] and partial response [PR]) by investigator review in participants with anaplastic thyroid canc...

Diagnosis: Head and Neck Cancer, Thyroid Cancer

Phase:

Protocol Number: 16-200

Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Study Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

The main purpose of this study is to compare nivolumab and ipilimumab with the Extreme study regimen as first line treatment in patients with recurrent or metastatic squamous cell of the head and n...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-402

Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

A study in patients with metastatic or recurrent squamous cell cancer of the head and neck to evaluate the effectiveness of Nivolumab plus Ipilumumab vs. Nivolumab alone (CheckMate 714)

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-438

A Phase IB/II Study With Azacitidine, Durvalumab, and Tremelimumab in Recurrent and/or Metastatic Head and Neck Cancer Patients

This is a non-randomized, open-label, Phase Ib/II study to assess the safety and efficacy of azacitidine, durvalumab (MEDI4736), and tremelimumab combination therapy in the treatment of patients wi...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-425

Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)

This is a phase 3 randomized, placebo controlled study to evaluate the safety and anti-tumor activity of Avelumab in combination with standard of care chemoradiation (SoC CRT) versus SoC CRT alone ...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-590

Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN

This research study is studying immunotherapy in combination with radiation therapy as a possible treatment for head & neck cancer that has worsened or spread to another organ or part of your b...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-604

Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma

This research study is studying immunotherapy with or without radiation therapy as a possible treatment for adenoid cystic carcinoma. The immunotherapy involved in this study is: - Pembrolizumab (M...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-609

Avelumab for Recurrent/Metastatic Nasopharyngeal Cancer

The purpose of this study is to determine whether avelumab, an investigational antibody against programmed death-ligand (PD-L1), has an effect on recurrent nasopharyngeal cancer. Avelumab is design...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 16-536

Nivolumab Plus Ipilimumab in Thyroid Cancer

This research study is studying nivolumab, an investigational drug, in combination with ipilimumab, also an investigational drug, as a possible treatment for thyroid cancer. The drugs involved in t...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 17-255

NC-6004 With 5-FU and Cetuximab for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Part 1 of this study will establish a recommended Phase II (RPII) dose for the triplet combination of NC-6004 plus 5-Fluorouracil (5-FU) and cetuximab. Part 2 will provide the efficacy signal of th...

Diagnosis: Head and Neck Cancer

Phase:

Protocol Number: 17-171

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