Head and Neck Cancer Clinical Trials
Category:Adult
Status:Active
Displaying all 27 Trial
The goal of this clinical research study is to compare the side effects of 2 radiation treatments for head and neck cancer. The 2 treatments are intensity modulated photon therapy (IMRT) and intens...
Diagnosis: Head and Neck Cancer, Radiation Oncology
Phase: 2 / 3
Protocol Number: 16-155
Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy
The purpose of this study is to test the hypothesis that 1)intensity-modulated radiotherapy (IMRT) or proton radiation therapy would result in improved local control rate and lowered toxicity compa...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number: 10-308
Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations
Phase II study to investigate the antitumor activity in terms of ORR of tipifarnib in subjects with advanced tumors that carry HRAS mutations and for whom there is no standard curative therapy avai...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number: 15-106
This randomized phase II trial studies how well iodine I-131works with or without selumetinib in treating patients with thyroid cancer that has returned or has spread from where it started to other...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number:
A Phase II Study of MLN0128 in Metastatic Anaplastic Thyroid Cancer
This research study is studying a targeted therapy (ML0N128) as a possible treatment for anaplastic thyroid cancer. This research study is a Phase II clinical trial. Phase II clinical trials test t...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number: 14-223
A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer
This research study is studying a targeted therapy as a possible treatment for thyroid cancer. A targeted therapy is a type of treatment that uses drugs or other substances to identify and attack s...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number: 15-350
Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity
This research study is studying nivolumab, an investigational drug, in combination with ipilimumab, also an investigational drug, as a possible treatment for Squamous Cell Carcinoma of the oral cav...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number: 16-284
Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma
The goal of this trial is to test the ability of MK-3475 (pembrolizumab) to improve locoregional recurrence and distant metastatic rates in high-risk patients with locally advanced head and neck sq...
Diagnosis: Head and Neck Cancer
Phase: 2
Protocol Number: 16-385
MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma
This research study is studying a targeted therapy as a possible treatment for merkel cell carcinoma. - The name of the study intervention involved in this study is: MLN0128.
Diagnosis: Head and Neck Cancer
Phase: 1 / 2
Protocol Number: 15-223
This research study is studying a vaccine, named DPX-E7, as a possible treatment for Human Papilloma Virus or HPV related head and neck, cervical or anal cancer (positive for HLA-A*02).
Diagnosis: Head and Neck Cancer
Phase: 1 / 2
Protocol Number: 15-578
This research study seeks to gain new knowledge about the addition of a carefully targeted "boost" dose of radiation as a possible treatment for recurrent or metastatic head or neck cance...
Diagnosis: Head and Neck Cancer, Radiation Oncology
Phase: 1
Protocol Number: 15-183
In-Room PET in Proton Radiation Therapy
The investigational part of this study is using a mobile PET/CT scanner to take images of the participants tumor immediately after they are treated with proton radiation. This allows the participan...
Diagnosis: Brain/Neuro Cancer: Supportive Care, Head and Neck Cancer
Phase: 0
Protocol Number: 10-241
Image-guided Cryoablation of Head, Neck and Spine Tumors
This research study is evaluating a procedure called cryoablation (the removal of diseased tissue using extreme freezing temperatures) as a possible treatment for head, neck and spine tumors.
Diagnosis: Head and Neck Cancer
Phase: N/A
Protocol Number: 13-458
This is a non-randomized, open-label, Phase Ib/II study to assess the safety and efficacy of azacitidine, durvalumab (MEDI4736), and tremelimumab combination therapy in the treatment of patients wi...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 16-425
Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN
This research study is studying immunotherapy in combination with radiation therapy as a possible treatment for head & neck cancer that has worsened or spread to another organ or part of your b...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 16-604
Avelumab for Recurrent/Metastatic Nasopharyngeal Cancer
The purpose of this study is to determine whether avelumab, an investigational antibody against programmed death-ligand (PD-L1), has an effect on recurrent nasopharyngeal cancer. Avelumab is design...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 16-536
Nivolumab Plus Ipilimumab in Thyroid Cancer
This research study is studying nivolumab, an investigational drug, in combination with ipilimumab, also an investigational drug, as a possible treatment for thyroid cancer. The drugs involved in t...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 17-255
This study is a multi-center, randomized, open label, Phase III clinical trial for advanced Nasopharyngeal Carcinoma(NPC) Patients. Drugs used in chemotherapy, such as gemcitabine and carboplatin, ...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 17-193
This research study is studying a combination of two immunotherapy drugs, as a possible treatment for locoregionally recurrent squamous cell carcinoma of the head and neck. The immunotherapy drugs ...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 17-411
This phase II trial studies how well pembrolizumab and lenvatinib work in treating patients with differentiated thyroid cancer that has spread to other places in the body or has come back and canno...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 16-616
There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-me...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 17-754
This study will evaluate the efficacy and safety of atezolizumab compared with placebo as adjuvant therapy after definitive local therapy in patients with high-risk locally advanced squamous cell c...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 17-685
This study has two, independent, cohorts, both in locally advanced squamous cell head and neck cancer. The purpose of the first cohort is to determine whether nivolumab in combination with radiothe...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 18-102
Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia
This research study is studying an immunotherapy drug, as a possible treatment for oral proliferative verrucous leukoplakia (OPVL).
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 18-387
This is a multicenter, randomized, double-blind study being conducted as a postmarketing requirement to the US Food and Drug Administration (FDA) to evaluate whether there is a lower starting dosag...
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 16-337
Primary Objectives: - Phase1: To characterize the safety and tolerability of isatuximab in combination with atezolizumab in participants with unresectable hepatocellular carcinoma (HCC), platinum-r...
Diagnosis: Brain/Neuro Cancer: Recurrent Glioblastoma, Head and Neck Cancer, GYN: Ovarian, Fallopian, Peritoneal Cancer, Liver Cancer
Phase:
Protocol Number: 18-332
Study of Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma
This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life.
Diagnosis: Head and Neck Cancer
Phase:
Protocol Number: 19-009
