Open Trials at Beth-Israel Deaconess Medical Center
Displaying trials 1 - 30 of 167 in total
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as flutamide, bicalutamide, and luteiniz...
Diagnosis: Prostate Cancer
Phase: 3
Defibrotide for Patients With Hepatic VOD: A Treatment IND Study
Single arm, open-label study to provide Defibrotide to patients diagnosed with VOD. Defibrotide is no longer available though the Emergency Use IND mechanism (also known as compassionate use, or si...
Diagnosis: Veno-Occlusive Disease
Phase: 3
This randomized study is looking at the benefits of using docetaxel (chemotherapy) added to one of the standard treatments (radiation and hormones) for men with high-risk prostate cancer.
Diagnosis: Prostate Cancer
Phase: 3
RATIONALE: Radiation therapy uses high-energy x-rays and other sources to damage tumor cells. Interstitial brachytherapy uses radioactive material placed directly into or near a tumor to kill tumor...
Diagnosis: None
Phase: 3
The drugs, lenalidomide, bortezomib, and dexamethasone, are approved by the FDA. They have not been approved in the combination for multiple myeloma or any other type of cancer. Bortezomib is curre...
Diagnosis: Multiple Myeloma
Phase: 3
This randomized phase III trial is studying giving lenalidomide and dexamethasone together with bortezomib to see how well it works compared to dexamethasone and lenalidomide alone in treating pati...
Diagnosis: None
Phase: 3
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stoppin...
Diagnosis: Colorectal Cancer, Gastrointestinal Malignancies
Phase: 3
The purpose of this study is to compare progression-free survival (PFS) (based upon investigator assessment using RECIST v1.1) in participants with platinum-resistant ovarian cancer who receive com...
Diagnosis: GYN: Ovarian, Fallopian, Peritoneal Cancer
Phase: 3
Immunotherapy Study for Surgically Resected Pancreatic Cancer
The purpose of this study is to assess overall survival after treatment with a regimen of adjuvant therapy (Gemcitabine alone or with 5-FU chemoradiation) with or without HyperAcute®-Pancreas (alge...
Diagnosis: Gastrointestinal Malignancies, Pancreatic Cancer
Phase: 3
This phase III clinical trial is studying ipilimumab or high-dose interferon alfa-2b in treating patients with high-risk stage III or stage IV melanoma that has been removed by surgery. Monoclonal ...
Diagnosis: Cutaneous Skin Cancer
Phase: 3
Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD)
The study objective is to compare the efficacy and safety of US-ATG-F as a supplement to standard of care prophylaxis versus standard of care prophylaxis alone in moderate to severe chronic GVHD-fr...
Diagnosis: Graft-versus-Host-Disease
Phase: 3
A Phase 3 Efficacy Study of a Recombinant Vaccinia Virus Vaccine to Treat Metastatic Prostate Cancer
The purpose of this study is to determine whether PROSTVAC alone or in combination with GM-CSF is effective in prolonging overall survival in men with few or no symptoms from metastatic, castrate-r...
Diagnosis: Prostate Cancer
Phase: 3
Purpose of this trial: 1. To assess the efficacy and safety of NeuVax(TM)a peptide (E75) vaccine administered with adjuvant Leukine(R)(sargramostim,GM-CSF). 2. To evaluate and compare the disease f...
Diagnosis: Breast: Early Stage Disease
Phase: 3
The purpose of the study is to determine whether the addition of Elotuzumab to Lenalidomide/low-dose Dexamethasone will increase the progression free survival (PFS)
Diagnosis: Multiple Myeloma
Phase: 3
Study of BMS-936558 vs. Everolimus in Pre-Treated Advanced Or Metastatic Clear-cell RCC
The purpose of the study is to compare the clinical benefit, as measured by duration of overall survival, of BMS-936558 vs. Everolimus in subjects with advanced or metastatic clear-cell renal cell ...
Diagnosis: Kidney Cancer
Phase: 3
This randomized phase III trial is studying gemcitabine hydrochloride, cisplatin, and bevacizumab to see how well they work compared with gemcitabine hydrochloride, cisplatin, and placebo in treati...
Diagnosis: Bladder Cancer
Phase: 3
This phase III clinical trial is studying how well giving tamoxifen citrate, anastrozole, letrozole, or exemestane with or without chemotherapy works in treating patients with invasive breast cance...
Diagnosis: Breast: Early Stage Disease
Phase: 3
Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY): Pilot Study
The purpose of this study is to determine whether, in patients undergoing primary bone tumor surgery, long-term (5 days)postoperative antibiotic regimens are more effective at decreasing the rate o...
Diagnosis: None
Phase: 3
The purpose of the study is to compare the response rate and overall survival of patients taking BMS-936558 to those taking study physician's choice of either Dacarbazine or Carboplatin and Pa...
Diagnosis: Cutaneous Skin Cancer
Phase: 3
The purpose of this phase 3, randomized, double-blind, multicenter study is to compare Oral MLN9708 plus Lenalidomide and Dexamethasone versus Placebo plus Lenalidomide and Dexamethasone in adult p...
Diagnosis: Multiple Myeloma
Phase: 3
The purpose of this study is to evaluate the effect of Idelalisib on the onset, magnitude, and duration of tumor control.
Diagnosis: Leukemia/MDS
Phase: 3
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as steroid 17alpha-monooxygenase TAK-700, when used with other hormone therapy, may lessen the amount of androgens ma...
Diagnosis: Prostate Cancer
Phase: 3
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. M...
Diagnosis: GYN: Ovarian, Fallopian, Peritoneal Cancer
Phase: 3
The purpose of the study is to evaluate whether treatment with ibrutinib as a monotherapy results in a clinically significant improvement in progression free survival (PFS) as compared to treatment...
Diagnosis: Leukemia/MDS
Phase: 3
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells...
Diagnosis: Colorectal Cancer, Gastrointestinal Malignancies
Phase: 2 / 3
Ponatinib for Squamous Cell Lung Cancer
This research study is a PHase II clinical trial, which tests the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer. "Invest...
Diagnosis: Lung Cancer
Phase: 2 / 3
Biomarker Trial of Everolimus in Patients With Advanced Renal Cell Carcinoma
The purpose of this study is to determine if certain features of tumor specimens sampled prior to therapy can predict for the likelihood of responding to everolimus.
Diagnosis: Kidney Cancer
Phase: 2
The purpose of this research study is to determine if armodafinil is safe and effective in treating fatigue in patients with malignant gliomas undergoing treatment with radiotherapy plus temodar. A...
Diagnosis: Brain/Neuro Cancer: Supportative Care
Phase: 2
Lapatinib in Combination With Trastuzumab in Patients With HER2-Positive, Metastatic Breast Cancer
In this research study we are studying the effects of the combination of lapatinib plus Herceptin in subjects with breast cancer that has spread outside of the breast. We are also studying whether ...
Diagnosis: Breast: Metastatic
Phase: 2
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as gemtuz...
Diagnosis: Leukemia/MDS
Phase: 2
